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Landmark epidemiologic study of chromate
production workers. The study took advantage of an extensive exposure
data base that was concurrent with employment history at the facility. Smoking
information was available for over 90% of the cohort, which is rare for historical
cohorts. The study is considered one of the most detailed occupational studies ever
conducted and is one of the critical studies used by the Occupational Safety and
Health Administration for its proposed Permissible Exposure Limit for chromium.
At the invitation of OSHA, a Sciences' expert testified at the public hearings
on the proposed PEL. The study resulted in two publications in the
American Journal of Industrial Medicine
(abstracts)
and one in Risk Analysis
(
abstract) as well as numerous presentations in scientific fora.
Evaluation of epidemiologic studies of
asbestos exposure.
Sciences has evaluated the vast epidemiologic literature on asbestos,
examining risks of mesothelioma, lung cancer, and asbestosis by occupational
and residential exposure, and the company maintains a large repository of
articles on the subject. The relationship of occupation to risk has been
further examined by the relative carcinogenic potency of fiber types,
dimension and quantity of exposure.
Analysis of birth defects data on
pharmaceutical.
Sciences analyzed the data regarding claims of a birth defect resulting
from use of a pharmaceutical. The analysis was prepared for presentation
at an FDA panel hearing. The analyses were subsequently described in a
letter to the journal where the issues were first raised. In the published
letter, the epidemiologic limitations of the original paper were described,
and proper epidemiologic approaches were recommended.
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